HPC server setup

Hi, 

I am setting up a new High performance machine as a server which will run all high fidelity FE and CFD models. What is the best way to set this up? 

It is a dual CPU (Epyc 7313) with multiple RTX 4000 GPU's and up to 2GB ram. 

Do I install Hyperworks directly onto the server OS or is it better to install Windows on a virtual machine and run hyper works of the VM?

I am running Windows server 2019 as the server OS, will this be compatible with the latest HW?

Any guidance will be appreciated, some high level bullet points will focus my research.

Thank you, 

Casper