Development of a novel high speed kneading granulation and analysis of its granulation mechanism by computer simulation
CorinneB_21985
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AUTHOR(S)
C. Aoki, H. Nakamura, H. Oishi, S. Watano, T. Hayuka, T. Iwasaki
PUBLISHER
Engineering Conferences International
SOURCE
Particulate Processes in the Pharmaceutical Industry III
YEAR
ABSTRACT
A novel “high speed kneading granulator” has been developed and its performance of wet granulation was evaluated using formulations containing high content of water-insoluble API. Also, the mixing performance, particle movement, impact frequency and energy etc. were analyzed by a computer simulation via a DEM (Discrete Element Method). Based on the information, granulation mechanism of the high speed kneading granulator was discussed.
KEYWORDS
Computer simulation, dem, Dispersion, High Speed Kneading Granulation, Mixing
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